Scientists to explore whether red wine chemical could help prevent bowel cancer

Scientists are embarking on an innovative study to investigate whether a chemical found in red grapes, red wine, and juice could potentially help in preventing bowel cancer. The research, called Colo-Prevent, aims to recruit 1,300 participants across 60 sites in England and Wales by early 2028. The study will focus on a purified form of resveratrol, a compound naturally occurring in red grapes and other fruits like blueberries, raspberries, and peanuts. Professor Karen Brown from the University of Leicester, an expert in translational cancer research, is leading the Colo-Prevent study. Previous work by Prof Brown has shown that purified resveratrol can inhibit the growth of cancer cells.

Participants sought for the study are aged between 50 and 73 and have been identified with bowel polyps through the NHS screening program. Bowel polyps, although usually benign, can develop into cancer if left untreated. The trial will involve the removal of polyps followed by the administration of aspirin and metformin or a combination of both, along with purified resveratrol or a placebo. Bowel cancer is a significant health concern, with around 44,000 people in the UK diagnosed annually. The cause is often unknown, but lifestyle changes such as regular exercise, a healthy diet, limited alcohol consumption, and not smoking can help reduce the risk.

Moreover, a groundbreaking trial named Colo-Prevent aims to recruit 20,000 participants at higher risk of developing bowel cancer. The trial involves sending a test kit for a faecal immunochemical test (FIT) to participants to detect early signs of bowel cancer. Dr. Iain Foulkes from Cancer Research UK, funding the trial, highlighted the potential of preventive strategies in cancer research. One participant, David Trusler, shared his motivation for joining the study, citing a family history of bowel cancer and a personal battle with prostate cancer.

The study’s objective is to prevent bowel cancer at its earliest stages through therapeutic prevention, in addition to lifestyle improvements. Screening for bowel cancer has advanced, but efforts to prevent its emergence are vital. The Colo-Prevent trial signifies a new era in cancer prevention, emphasising cutting-edge science for a cancer-free future. The insights gained from the study are expected to revolutionise cancer prevention strategies, offering hope for longer and healthier lives. By participating in such trials, individuals like David Trusler aim to contribute to a future where cancer is more preventable and lives are saved.

Insights and Summary:
The Colo-Prevent study represents a significant step forward in cancer research, particularly in the prevention of bowel cancer. By investigating the potential benefits of a chemical found in red grapes, researchers are exploring new ways to combat a prevalent and deadly disease. The study’s focus on preventive measures, along with lifestyle changes, underscores the importance of early detection and intervention in reducing cancer risks. Engaging with such trials not only contributes to scientific advancements but also offers hope for a future where cancer is more preventable and manageable.